Evaluation of the implant-bone interface integration using PRGF in the dog jaw

Evaluation of the implant-bone interface integration using PRGF in the dog jaw

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Introduction: It has been demonstrated that use of plasma rich in growth factors produces a dynamic surface on the implants, which accelerates the healing process.This study undertook a histologic and histomorphometric evaluation of the effect of platelet-rich growth factors (PRGF) on the amount of bone regeneration around dental implants.Materials and Methods: In this animal-intervention study, two systemically healthy Persian mix-breed dogs were selected.

Three months after extraction of the dogs’ mandibular premolars on both sides, 12 implants were selected from the OIC system with a length of 10 mm and a diameter Patio Sectional of 5 mm.Six implants were placed in the osteotomy cavities using growth factors and 6 others were placed in the osteotomy cavities without PRGF.After 12 weeks, all the implants were removed along with the surrounding bone using Gift Cards Trephine bur.

The samples were evaluated under a light microscope subsequent to sectioning.Data were analyzed with t-test and Mann-Whitney test (α = 0.05).

Results: The results of the present study indicated that histologically, there was a significant increase in the amount of regenerated bone around the implants; moreover, thickness and maturity of bony trabeculae were not different in the samples containing PRGF in comparison with the control samples.Conclusion: According to the results, implant-bone interface integration rate around dental implants coated with PRGF was higher compared to the control group Key words: Animal study, Dental implants, Growth factor, Histomorphometry, Histology, Plasma.